Chandy C John Selected Research

Cerebral Malaria

1/2022	Elevated Plasma Soluble ST2 Levels are Associated With Neuronal Injury and Neurocognitive Impairment in Children With Cerebral Malaria.
1/2022	Impact of Oxidative Stress on Risk of Death and Readmission in African Children With Severe Malaria: A Prospective Observational Study.
1/2021	Adipose tissue parasite sequestration drives leptin production in mice and correlates with human cerebral malaria.
1/2021	Parenteral artemisinins are associated with reduced mortality and neurologic deficits and improved long-term behavioral outcomes in children with severe malaria.
10/2020	The impact of delayed treatment of uncomplicated P. falciparum malaria on progression to severe malaria: A systematic review and a pooled multicentre individual-patient meta-analysis.
1/2020	Delayed iron improves iron status without altering malaria risk in severe malarial anemia.
1/2020	Elevated Cerebrospinal Fluid Tau Protein Concentrations on Admission Are Associated With Long-term Neurologic and Cognitive Impairment in Ugandan Children With Cerebral Malaria.
1/2020	Endothelial Activation, Acute Kidney Injury, and Cognitive Impairment in Pediatric Severe Malaria.
10/2019	Autoantibody levels are associated with acute kidney injury, anemia and post-discharge morbidity and mortality in Ugandan children with severe malaria.
1/2018	Lack of mortality in 22 children with sickle cell anemia and severe malarial anemia.

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Chandy C John Research Topics

Disease

86	Malaria 10/2022 - 04/2002
30	Cerebral Malaria 01/2022 - 09/2006
26	Infections 09/2021 - 08/2003
18	Anemia 01/2022 - 09/2004
14	Inflammation (Inflammations) 11/2021 - 07/2011
9	Sickle Cell Anemia (Hemoglobin S Disease) 10/2022 - 06/2016
7	Acute Kidney Injury (Acute Renal Failure) 10/2022 - 10/2016
7	Parasitemia 11/2021 - 03/2012
7	Falciparum Malaria (Plasmodium falciparum Malaria) 11/2021 - 03/2008
7	Fever (Fevers) 10/2020 - 04/2014
5	Coma (Comas) 10/2022 - 01/2015
5	Hemolysis 01/2020 - 04/2016
5	Iron Deficiencies 01/2020 - 09/2014
4	Cognitive Dysfunction 01/2020 - 09/2006
3	COVID-19 01/2022 - 10/2020
3	Neurologic Manifestations (Neurological Manifestations) 01/2021 - 02/2008
3	Thrombocytopenia (Thrombopenia) 10/2020 - 07/2015
3	Communicable Diseases (Infectious Diseases) 01/2017 - 03/2008
3	Reinfection 07/2013 - 04/2002
2	Acidosis 10/2022 - 11/2016
2	Kidney Diseases (Kidney Disease) 10/2022 - 01/2022
2	Brain Injuries (Brain Injury) 12/2021 - 09/2006
2	Malnutrition (Nutritional Deficiencies) 10/2021 - 10/2017
2	Severe Acute Malnutrition 12/2020 - 01/2019
2	HIV Infections (HIV Infection) 12/2020 - 08/2019
2	Critical Illness (Critically Ill) 10/2020 - 11/2016
2	Bites and Stings (Sting) 01/2019 - 10/2009
2	Central Nervous System Infections (Central Nervous System Infection) 01/2017 - 02/2008
1	Hyperkalemia 10/2022
1	Pain (Aches) 10/2022

Drug/Important Bio-Agent (IBA)

23	AntigensIBA 12/2020 - 08/2003
20	AntibodiesIBA 01/2021 - 08/2003
15	Proteins (Proteins, Gene)FDA Link 01/2021 - 09/2004
13	Hemoglobins (Hemoglobin)IBA 11/2021 - 02/2008
12	Biomarkers (Surrogate Marker)IBA 10/2022 - 01/2009
12	Immunoglobulin G (IgG)IBA 01/2022 - 04/2002
10	CytokinesIBA 11/2021 - 09/2006
9	VaccinesIBA 12/2020 - 07/2004
9	Antimalarials (Antimalarial Agents)IBA 01/2020 - 07/2011
8	IronIBA 01/2022 - 09/2014
8	Merozoite Surface Protein 1 (MSA1)IBA 01/2017 - 11/2003
7	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 11/2021 - 09/2006
7	Interleukin-10 (Interleukin 10)IBA 01/2020 - 04/2006
7	Nitric Oxide (Nitrogen Monoxide)FDA Link 02/2018 - 07/2011
7	ThrombospondinsIBA 01/2017 - 09/2004
6	InterferonsIBA 01/2017 - 09/2006
6	Interferon-gamma (Interferon, gamma)IBA 01/2016 - 11/2003
6	EnzymesIBA 10/2014 - 07/2004
5	ArtesunateIBA 10/2022 - 07/2015
5	Angiopoietin-2IBA 11/2021 - 07/2011
5	Immunoglobulin M (IgM)IBA 01/2021 - 07/2005
5	Hydroxyurea (Hydrea)FDA LinkGeneric 01/2020 - 06/2016
5	ChemokinesIBA 07/2015 - 09/2006
5	ImmunosorbentsIBA 10/2014 - 09/2004
4	artemisinin (artemisinine)IBA 01/2021 - 12/2009
4	Lumefantrine Drug Combination Artemether (Coartem)FDA Link 12/2020 - 12/2009
4	Heme (Haem)IBA 01/2020 - 10/2016
4	Peptides (Polypeptides)IBA 10/2013 - 04/2002
3	CreatinineIBA 10/2022 - 01/2020
3	C-Reactive ProteinIBA 12/2020 - 09/2014
3	Ferritins (Ferritin)IBA 12/2020 - 09/2014
3	Intercellular Adhesion Molecule-1 (Intercellular Adhesion Molecule 1)IBA 01/2020 - 03/2012
3	Interleukin-6 (Interleukin 6)IBA 07/2015 - 09/2006
3	Chemokine CCL5IBA 07/2015 - 09/2006
3	Pharmaceutical PreparationsIBA 07/2013 - 07/2003
2	Sickle HemoglobinIBA 11/2021 - 07/2013
2	DNA (Deoxyribonucleic Acid)IBA 09/2021 - 10/2019
2	artenimol (dihydroartemisinin)IBA 12/2020 - 11/2018
2	piperaquineIBA 12/2020 - 11/2018
2	MicronutrientsIBA 12/2020 - 10/2017
2	Transferrin Receptors (Transferrin Receptor)IBA 01/2020 - 09/2014
2	L-Lactate Dehydrogenase (Lactate Dehydrogenase)IBA 01/2020 - 01/2019
2	Kynurenic Acid (Kynurenate)IBA 01/2020 - 01/2017
2	Glucose (Dextrose)FDA LinkGeneric 01/2020 - 04/2014
2	zinc protoporphyrinIBA 01/2020 - 01/2017
2	von Willebrand FactorIBA 01/2020 - 03/2012
2	Biological ProductsIBA 08/2019 - 09/2011
2	Immunoglobulins (Immunoglobulin)IBA 08/2019 - 02/2015
2	Endothelial Protein C ReceptorIBA 10/2017 - 01/2016
2	insulin receptor-related receptor (IRR)IBA 09/2017 - 01/2017
2	Histidine (L-Histidine)FDA Link 01/2017 - 08/2012
2	Lactic Acid (Lactate)FDA LinkGeneric 11/2016 - 04/2014
2	Malaria VaccinesIBA 10/2015 - 07/2004
2	Toll-Like Receptors (Toll-Like Receptor)IBA 02/2012 - 04/2010
2	Granulocyte Colony-Stimulating Factor (G-CSF)IBA 03/2008 - 02/2008
2	Interleukin-1 Receptors (Interleukin 1 Receptor)IBA 03/2008 - 02/2008
2	InterleukinsIBA 02/2008 - 09/2006
1	Urea (Carbamide)FDA LinkGeneric 10/2022
1	NitrogenIBA 10/2022
1	Lipocalin-2IBA 10/2022
1	Interleukin-33IBA 01/2022
1	TeaIBA 01/2022

Therapy/Procedure

21	Therapeutics 01/2022 - 08/2006
4	Chemoprevention 12/2020 - 11/2018
4	Blood Transfusion (Blood Transfusions) 01/2018 - 01/2016
3	Aftercare (After-Treatment) 10/2022 - 09/2004
3	Cognitive Training 08/2011 - 09/2006
2	Patient Readmission 10/2021 - 10/2019
2	Treatment Delay 10/2020 - 01/2020
2	Ambulatory Care (Outpatient Care) 09/2017 - 01/2017